Core Faculty

Samuel Stupp

Samuel Stupp

Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine and Biomedical Engineering

Director, Louis A. Simpson and Kimberly K. Querrey Center for Regenerative Nanomedicine

Director, Simpson Querrey Institute for BioNanotechnology

2220 Campus Drive

Cook Hall 2036; Office - Cook 1127

Evanston, IL 60208

s-stupp( at )northwestern.edu

Education

Ph.D. Materials Science and Engineering, Northwestern University, Evanston, IL

B.S. Chemistry, University of California at Los Angeles, Los Angeles, CA

Research Interests

Research in the Stupp group is highly interdisciplinary, integrating chemistry, materials science, and medicine. The main interest of the group is the development of self-assembling organic materials, focusing on functions relevant to energy and medicine.  The laboratory is currently interested on nanostructures and materials for solar photovoltaics and solar fuels, ferroelectrics for memories, regenerative medicine, and cancer therapies.  The group has three different subgroups: self-assembly, energy materials, and biomaterials.  Research includes molecular synthesis, characterization of structure, measurement of materials properties, cell biology, and in vivo studies of the efficacy of nanostructures and materials in medical applications.  

The self-assembly subgroup works on programming of molecules to create functional supramolecular assemblies based on small molecules, polymers, and inorganic structures. The systems of interest at the moment include artificial cells which may have biomedical functions or serve as chemical microreactors, ferroelectric molecular assemblies based on electron transfer, and arrays of aligned nanofibers for tissue engineering of arteries.  This sub-group focuses on all aspects of self-assembly including molecular synthesis, characterization of structure by electron microscopy, synchrotron small angle x-ray scattering, electron paramagnetic resonance, spectroscopic techniques, and computer simulations.

The energy materials subgroup is focused on the integration of self-assembly into solar photovoltaic devices and supramolecular catalytic systems for solar fuel production.  Current targets include hybrid materials based on inorganic semiconductors and organic electronic materials, organic photovoltaic systems targeting designs for molecular recognition between electron acceptors and donors, and photosynthetic gels in which self-assembly processes optimize the function of catalysts for hydrogen production.

The biomaterials subgroup focuses on the development of bioactive materials that can signal cells for targets in regenerative medicine.  The regenerative medicine targets include spinal cord injury, Parkinson's disease, heart regeneration, diabetes, bone, cartilage, and muscle.  This subgroup also investigates novel cancer therapies based on supramolecular nanofibers targeting apoptosis of cells.  The research includes molecular design of self-assembling nanostructures that optimize cell signaling for regeneration, mediate cell death vs. cell survival, and guide differentiation of stem cells.  A developing interest is the use of supramolecular nanostructures for genetic reprogramming.  In this area work has been initiated to create virus-like structures that could carry nucleic acids into cells.

Significant Recognition

  • International Award, The Society of Polymer Science, Japan (2014)
  • President, International Scientific Committee of the Institute for Bioengineering of Catalonia, Spain (2014)
  • Distinguished Visiting Professor of Biochemistry, University of Hong Kong (2014)
  • Creation of the Samuel I. Stupp Prize in Nanotechnology by the Ministry of Science and Technology, Government of Costa Rica (2013)
  • Honorary Doctorate from the University of Gothenburg, Sweden Medical School (2013)
  • Australian Centre for Nanomedicine Annual Visiting Professorship (2013)
  • American Chemical Society Ronald Breslow Award for Achievement in Biomimetic Chemistry (2012)
  • Member, National Academy of Engineering (2012)
  • Member, Royal Spanish Academy of Pharmacy (2012)
  • Honorary Doctorate, National University of Costa Rica (2011)
  • Thomson Reuters Top 100 Chemists for 2000-2010 (2011)
  • Fellow, Materials Research Society (2009)
  • Distinguished Professorship, Eindhoven University of Technology (2009)
  • Israel Pollack Distinguished Lecture Series Award, Technion-Israel Institute of Technology (2009)
  • Honorary Doctorate for Revolutionary Research in Complex Molecular Systems, Eindhoven University of Technology (2009)
  • American Chemical Society Award in Polymer Chemistry (2005)
  • Fellow, World Technology Network (2003)
  • Materials Research Society Medal Award (2000)
  • Humboldt Award for Senior U.S. Scientists (1997)
  • U.S. Department of Energy Prize for Outstanding Scientific Accomplishment in Materials Chemistry (1991)
  • Xerox Faculty Award for Excellence in Engineering Research (1985)
  • 3M Young Faculty Award (1981)
  • 3M Young Faculty Award (1981)
  • 3M Young Faculty Award (1981)

Significant Professional Service

  • Organizer and Co-Chair of the Inter-Agency Materials Genome Initiative Soft Matter Summit, Washington DC (2013)
  • Member, RIKEN Center for Emergent Matter Science Advisory Council, Japan (2013)
  • Member, Scientific Advisory Board, Xeltis Corporation, Zurich, Switzerland (2013)
  • Co-Chair, Gordon Research Conference on Self-Assembly & Supramolecular Chemistry in Les Diablerets, Switzerland (2013)
  • Honorary Membership, Israel Chemical Society (2009)
  • Member, World Premier International Program Advisory Committee to Advanced Institute for Materials Research, Japan Society for the Promotion of Science, Japan (2008)
  • International Advisory Group, Swedish Government Program on Biomaterials, Gothenburg University (2008)
  • Member, Scientific Advisory Board, University of Vienna (2006)
  • Merck-Karl Pfister Visiting Professorship, Massachusetts Institute of Technology (2004)
  • Member, Scientific Advisory Board, National University of Singapore (2003)
  • Member, Baxter Scientific Advisory Board (2001)
  • Member, Solid State Sciences Committee, National Academy of Sciences (2001)
  • Member, Basic Energy Sciences Advisory Committee, Department of Energy (1999)
  • Elected member of American Academy of Arts and Sciences (1998)
  • Fellow of American Association for the Advancement of Science (1999)
  • Joliot Curie Professorship, Ecole Supérieure de Physique et de Chimie Industrielles (1997)
  • Member, Materials Panel, Air Force Scientific Advisory Board (1995)
  • Exclusive consultant to 3M Company (1987)

Selected Publications

    Boekhoven, J.; Stupp, S. I. “Supramolecular Materials for Regenerative Medicine” Advanced Materials 2014, 26(11), 1642-1659.  

    Newcomb, C. J.; Sur, S.; Ortony, J. H.; Lee, O-S.; Matson, J. B.; Boekhoven, J.; Yu, J-M.; Schatz, G. C.; Stupp, S. I. “ Cell Death Versus Cell Survival Instructed by Supramolecular Cohesion of Nanostructures” Nature Communications 2014, 5(3321), 1-10. 

    Berns, E. J.; Sur, S.; Pan, L.; Goldberger, J. E.; Suresh, S.; Zhang, S.; Kessler, J. A.; Stupp, S. I. “Aligned Neurite Outgrowth and Directed Cell Migration in Self-Assembled Monodomain Gels” Biomaterials 2014, 35(1), 185-195. 

    Lee, S. S.; Hunag, B. J.; Kaltz, S. R.; Sur, S.; Newcomb, C. J.; Stock, S. R.; Shah, R. N.; Stupp, S. I. “Bone Regeneration with Low Dose BMP-2 Amplified by Biomimetic Supramolecular Nanofibers within Collagen Scaffolds” Biomaterials 2013, 34(2), 452-459.            

    Ruff, Y.; Moyer, T.; Newcomb, C. J.; Demeler, B.; Stupp, S.I. “Precision Templating with DNA of a Virus Like Particle with Peptide Nanostructures” JACS 2013, 135(16), 6211-6219.

    Boekhoven, J.; Pérez, C. R.; Sur, S.; Worthy, A.; Stupp, S. I.; “Dynamic Display of Bioactivity through Host-Guest Chemistry” Angew. Chem. Int. Ed. 2013,52(46), 12077-12080. 

    Stephanopoulos, N.; Ortony, J. H.; Stupp, S. I. “Self-Assembly for the Synthesis of Functional Biomaterials” Acta Materialia 2013, 61(3), 912-930. 

    Zha, R. H.; Sur, S.; Stupp, S. I. “Self-Assembly of Cytotoxic Peptide Amphiphiles into Supramolecular Membranes for Cancer Therapy” Advanced Healthcare Materials 2013, 2(1), 126-133.

    Tayi, A. S.; Shveyd, A. K.; Sue, C-H.; Szarko, J. M.; Rolczynski, B. S.; Cao, D.; Kennedy, T. J.; Sarjeant, A. A.; Stern, C. L.; Paxton, W. F.; Wu, W.; Dey, S. K.; Fahrenbach, A. C.; Guest, J. R.; Mohseni, H.; Chen, L. X.; Wang, K. L.; Stoddart, J. F.; Stupp, S. I. “Room-Temperature Ferroelectricity in Supramolecular Networks of Charge-Transfer Complexes” Nature 2012, 488, 485-489.

    Aida, T.; Meijer, E. W.; Stupp, S. I. “Functional Supramolecular Polymers” Science 2012, 335(6070), 813-817. 

    Velichko, Y. S.; Mantei, J. R.; Bitton, R.; Carvajal, D.; Shull, K. R.; Stupp, S. I.  “Electric Field Controlled Self-Assembly of Hierarchically Ordered Membranes” Advanced Functional Materials 2012, 22(2), 369-377.

    Matson, J.; Stupp, S. I. “Self-Assembling peptide scaffolds for Regenerative Medicine” Chemical Communications 2012, 48(1), 26-33.

    Tevis, I. D.; Palmer, L. C.; Herman, D. J.; Murray, I. P.; Stone, D. A.; Stupp, S. I. “Self-Assembly and Orientation of Hydrogen-Bonded Oligothiophene Polymorphs at Liquid-Membrane-Liquid Interfaces” J. Am. Chem. Soc. 2011, 133(41), 16486-16494.

    Goldberger, J. E.; Berns, E. J.; Bitton, R.; Newcomb, C. J.; Stupp, S. I. “Electrostatic Control of Bioactivity” Angew. Chem. Int. Ed. 2011, 50(28), 6292-6295.

    Rożkiewicz, D. I.; Myers, B. D.; Stupp, S. I. “Interfacial Self-Assembly of Cell-like Filamentous Microcapsules” Angew. Chem. Int. Ed. 2011, 50(28), 6324-6327.

    Webber, M. J.; Tongers, J.; Newcomb, C. J.; Marquardt, K-T.; Bauersachs, J.; Losordo, D. W.; Stupp, S. I. “Supramolecular Nanostructures that Mimic VEGF as a strategy for Ischemic Tissue Repair” Proc. Natl. Acad. Sci. 2011, 108(33), 13438-13443.

    Huang, Z.; Newcomb, C. J.; Bringas, P.; Stupp, S. I.; Snead, M. L. “Biological Synthesis of Tooth Enamel Instructed by an Artificial Matrix” Biomaterials 2010, 31(35), 9202-9211. 

    Stupp, S. I. “Self-Assembly and Biomaterials” Nano Letters 2010, 10(12), 4783-4786. 

    Shah, R. M.; Shah, N. A.; Del Rosario Lim, M. M.; Hsieh, C.; Nuber, G.; Stupp,  S. I. “Supramolecular Design of Self-Assembling Nanofibers for Cartilage Regeneration” Proc. Natl. Acad. Sci. 2010, 107(8), 3293-3298.

    Mata, A.; Geng, Y.; Henrikson, K.; Aparicio, C.; Stock, S.; Satcher, R. L.; Stupp, S. I. “Bone Regeneration Mediated by Biomimetic Mineralization of a Nanofiber Matrix” Biomaterials 2010, 31(23), 6004-6012. 

    Pashuck, E. T.; Cui, H.; Stupp, S. I. “Tuning Supramolecular Rigidity of Peptide Fibers through Molecular Structure”J. Am. Chem. Soc. 2010, 132(17), 6041-6046. 

    Shah, R. M.; Shah, N. A.; Del Rosario Lim, M. M.; Hsieh, C.; Nuber, G.; Stupp,  S. I. “Supramolecular Design of Self-Assembling Nanofibers for Cartilage Regeneration” Proc. Natl. Acad. Sci. 2010, 107(8), 3293-3298.

    Zhang, S.; Greenfield, M. A.; Mata, A.; Palmer, L. C.; Bitton, R.; Mantei, J. R.; Aparicio, C.; Olvera de la Cruz, M.; Stupp, S. I. “A Self-Assembly Pathway to Aligned Monodomain Gels” Nature Materials 2010, 9(7), 594-601. 

    Cui, H.; Pashuck, E. T.; Velichko, Y. S.; Weigand, S. J.; Cheetham, A. G.; Newcomb, C. J.; Stupp, S. I. “Spontaneous and X-Ray Triggered Crystallization at Long Range in Self-Assembling Filament Networks” Science 2010, 327(5965), 555-559.

    Sofos, M.; Goldberger, J.; Stone, D. A.; Allen, J. E.; Ma, Q.; Herman, D. J.; Tsai. W-W.; Lauhon, L. J.; Stupp. S. I. “A Synergistic Assembly of Nanoscale Lamellar Photoconductor Hybrids” Nature Materials 2009, 8(1), 68-75.

     

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